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In Zeberg and Pääbo (2020), Figure 1a is showing a Manhattan plot. The Y-axis is significance, but what is it showing the significance of? (10 points)
In Figure 1B, the bar represents the core Neanderthal haplotype. There is near-complete LD of variants within this core haplotype. However, LD with variants starts to drop outside of this core haplotype. Why? (10 points)
Look at Extended Data Figure 2 of Zeberg and Pääbo (2020). In the depicted genomic region (~45.72-46.58), where is recombination most active? Explain your answer. (10 points)
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